The Springboks will be without Frans Steyn for the third Test, as the backline ace will be getting married on Saturday.
The 25-year-old hasn't traveled with the rest of the team to Port Elizabeth and will be saying his vows and not backline calls on Saturday.
The medical team will also be monitoring lock Juandré Kruger (neck), flank Willem Alberts (knee) and fullback Pat Lambie (ankle) over the next few days to determine their availability.
Kruger went for precautionary x-rays and a scan on Saturday evening and according to team doctor Craig Roberts everything is clear.
Alberts, who injured the medial collateral ligaments in his right knee, as well as Lambie, who twisted his left ankle, will be assessed in the coming days.
"They will be treated by our medical team in the next few days and we will decide by Wednesday, when we name the team, whether they will play or not," said Springbok coach Heyneke Meyer.
The Boks have already lost prop Coenie Oosthuizen and fullback Zane Kirchner to injuries, and a decision on possible replacements will be taken at a later stage in the week.