England coach Stuart Lancaster has been forced to make a late change to his starting front row with Joe Marler coming in for the injured Alex Corbisiero.
Corbesiero got the nod to start at loosehead ahead of Marler thanks to a convincing performance off the bench in Johannesburg last week, but has been sidelined with a recurrence of a knee complaint.
As a result Marler will start in the No.1 jersey again, with Paul Doran Jones coming on to the replacements' bench.
Lancaster said: "Alex trained well early in the week having played well at the weekend but the knee reacted over the last 24 hours.
"It is a shame for Alex as he was desperate to take part but it’s the right thing to put in Joe and we are sure he can build on his performances in the first two Tests," he added.
Revised England team: 15 Alex Goode, 14 Chris Ashton, 13 Jonathan Joseph, 12 Manusamoa Tuilagi, 11 Ben Foden, 10 Toby Flood, 9 Danny Care, 8 Thomas Waldrom, 7 James Haskell, 6 Tom Johnson, 5 Geoff Parling, 4 Tom Palmer, 3 Dan Cole, 2 Dylan Hartley (captain), 1 Joe Marler.
Replacements: 16 Lee Mears, 17 Paul Doran Jones, 18 Mouritz Botha, 19 Phil Dowson, 20 Lee Dickson, 21 Owen Farrell, 22 Brad Barritt.
Date: Saturday, June 23
Venue: Nelson Mandela Bay Stadium, Port Elizabeth
Kick-off: 17.05 (15.05 GMT)
Referee: Steve Walsh (Australia)
Assistant referees: Nigel Owens (Wales), John Lacey (Ireland)
TMO: Giulio De Santis (Italy)