The Western Force were dealt a cruel blow ahead of the farewell match for veteran Nathan Sharpe.
Tighthead prop Salesi Ma'afu fractured his arm in a training ground mishap ahead of their encounter with the Brumbies in Perth on Saturday.
The Wallaby front row forward will miss the rest of the season.
Salesi Manu will start his first game for the Force, with a decision on the make-up of the replacements to be made later.
Western Force - revised: 15 Alfie Mafi, 14 Nick Cummins, 13 Will Tupou, 12 Rory Sidey, 11 Napolioni Nalaga, 10 Ben Seymour, 9 Josh Holmes, 8 Matt Hodgson, 7 David Pocock (captain), 6 Richard Brown, 5 Nathan Sharpe, 4 Toby Lynn, 3 Salesi Manu, 2 Nathan Charles, 1 Pek Cowan.
Replacements: 16 Elvis Taione, 17 Tetera Faulkner, 18 TBC, 19 Phoenix Battye, 20 Lachlan McCaffrey, 21 Brett Sheehan, 22 David Harvey.
Date: Saturday, July 30
Venue: nib Stadium, Perth
Kick-off: 17.40 (09.40 GMT)
Referee: Ian Smith (Australia)
Assistant referees: James Leckie (Australia), Ed Martin (Australia)
TMO: George Ayoub (Australia)