Only one new cap in the starting XV
There will be a family 'feud' in Dublin on Saturday when cousins Richard Strauss and Adriaan Strauss confront each other for the first time in a Test.
Richard Strauss was on Thursday named to start for Ireland at hooker in Dublin on Saturday, with cousin Adriaan Strauss starting for South Africa.
Jamie Heaslip will captain Ireland in the opening round of November Tests.
The Leinster No.8 will be leading his country for the first time - a side that contains one new cap in the starting team and a further three uncapped players among the replacements.
Richardt Strauss will earn his first cap for Ireland at hooker in the front row, alongside his provincial colleagues Cian Healy and Mike Ross.
Mike McCarthy is selected in the second row alongside Donnacha Ryan, with Chris Henry selected to start at openside in the back row, with Peter O'Mahony selected at blindside.
In the backs, Simon Zebo will be earning his first start for Ireland at full back, in a back three that has plenty of experience in Andrew Trimble and Tommy Bowe, who will be earning his 50th international cap for Ireland since making his debut against the USA in 2004.
Jonathan Sexton and Conor Murray are selected as the halfbacks with Gordon D'Arcy and Keith Earls completing the starting lineup as the centre partnership.
Among the replacements, forwards David Kilcoyne, Michael Bent and Iain Henderson are all in line to make their international debuts should they be called into the game.
Ireland: 15 Simon Zebo, 14 Tommy Bowe, 13 Keith Earls, 12 Gordon D'Arcy, 11 Andrew Trimble, 10 Jonathan Sexton, 9 Conor Murray, 8 Jamie Heaslip (captain), 7 Chris Henry, 6 Peter O'Mahony, 5 Mike McCarthy, 4 Donnacha Ryan, 3 Mike Ross, 2 Richardt Strauss, 1 Cian Healy.
Replacements: 16 Sean Cronin, 17 David Kilcoyne, 18 Michael Bent, 19 Donncha O'Callaghan, 20 Iain Henderson, 21 Eoin Reddan, 22 Ronan O'Gara, 23 Fergus McFadden.
Date: Saturday, November 10
Venue: Aviva Stadium, Dublin
Kick-off: 17.30 (17.30 GMT)
Referee: Wayne Barnes (England)
Assistant referees: Steve Walsh (Australia), Luke Pierce (England)
TMO: Giulio De Santis (Italy)