The support of the country has been great throughout the tournament
Flyhalf Owen Farrell returns to the England starting line-up for Saturday's Six Nations title decider against Wales at the Millennium Stadium.
The Saracens playmaker will be joined at scrumhalf by Ben Youngs, while Toby Flood and Danny Care will be among the replacements.
There are two changes to the pack that started against Italy with Joe Marler replacing Mako Vunipola at loosehead prop and Tom Croft starting at blindside flank in place of James Haskell.
Coach Stuart Lancaster said: "We have come a long way through the Six Nations and we want to finish well on what will be a fantastic occasion in Cardiff.
"It will be a great experience for our English team. Every single player, whether they are in the 23 or not this Saturday, has contributed to getting us in this position and they should be proud of that.
"The support of the country has been great throughout the tournament and I am sure they will be right behind us come 5 o'clock."
England: 15 Alex Goode, 14 Chris Ashton, 13 Manu Tuilagi, 12 Brad Barritt, 11 Mike Brown, 10 Owen Farrell, 9 Ben Youngs, 8 Tom Wood, 7 Chris Robshaw (captain), 6 Tom Croft, 5 Geoff Parling, 4 Joe Launchbury, 3 Dan Cole, 2 Tom Youngs, 1 Joe Marler.
Replacements: 16 Dylan Hartley, 17 David Wilson, 18 Mako Vunipola, 19 Courtney Lawes, 20 James Haskell, 21 Danny Care, 22 Toby Flood, 23 Billy Twelvetrees.
Date: Saturday, March 16
Venue: Millenium Stadium, Cardiff
Kick-off: 17.00 (17.00 GMT)
Referee: Steve Walsh (Australia)
Assistant referees: Craig Joubert (South Africa), John Lacey (Ireland)
TMO: Marshall Kilgore (Ireland)