Bulls flank Dewald Potgieter was ruled out of Saturday's all-South African Super Rugby clash with the Kings.
The Springbok loose forward sustained a knee injury in training and will be replaced by Arno Botha.
Botha, who was named on the bench, will start in the No.7 jersey, with another Bok loose forward Jacques Potgieter moving onto the bench.
The new loose trio combination of Pierre Spies, Botha and Deon Stegmann has played together on two occasions already this year - against the Blues in Auckland and the Crusaders in Christchurch.
Bulls - revised: 15 Jürgen Visser, 14 Akona Ndungane, 13 JJ Engelbrecht, 12 Jan Serfontein, 11 Lionel Mapoe, 10 Morné Steyn, 9 Jano Vermaak, 8 Pierre Spies (captain), 7 Arno Botha, 6 Deon Stegmann, 5 Juandrè Kruger, 4 Flip van der Merwe, 3 Frik Kirsten, 2 Chiliboy Ralepelle, 1 Morné Mellett.
Replacements: 16 Callie Visagie, 17 Werner Kruger, 18 Paul Willemse, 19 Jacques Potgieter, 20 Rudi Paige, 21 Louis Fouché, 22 Bjorn Basson.
Date: Saturday, April 20
Venue: Nelson Mandela Bay Stadium, Port Elizabeth
Kick-off: 19.10 (17.10 GMT)
Referee: Francisco Pastrana (Argentina)
Assistant referees: Ben Crouse (South Africa), Christie du Preez (South Africa)
TMO: Johann Meuwessen (South Africa)