I cannot remember so many injuries from one Test
Scotland included three new caps in the team to face South Africa in the second round of a four-nation tournament in Nelspruit on Saturday.
The debutants for the game at Mbombela Stadium, a new Test venue, are fullback Peter Murchie, right wing Tommy Seymour and lock Tim Swinson.
Coach Scott Johnson has made seven changes to the side beaten 27-17 by Samoa last weekend in a bruising first-round clash.
Flyhalf Ruaridh Jackson, hooker Scott Lawson, lock Jim Hamilton and flank Ryan Wilson are the others elevated to the starting line-up.
Tour-ending injuries ruled out captain and loose forward Kelly Brown and hooker Pat MacArthur and concussed flyhalf Tom Heathcote is rested.
Lock Alastair Kellock drops to the bench while the axe fell on fullback Greig Tonks, left wing Tim Visser and lock Grant Gilchrist.
Australian Johnson said the casualty list after the Samoa loss - which ran into double figures - was the longest he had known in his coaching career.
"I cannot remember so many injuries from one Test, but it is a fact and we just have to get on with it," he said.
"We wanted to find out about players through this tour and, because of circumstances, that process is being accelerated."
Scotland: 15 Peter Murchie, 14 Tommy Seymour, 13 Alex Dunbar, 12 Matt Scott, 11 Sean Lamont, 10 Ruaridh Jackson, 9 Greig Laidlaw (captain), 8 Johnnie Beattie, 7 Ryan Wilson, 6 Alasdair Strokosch, 5 Jim Hamilton, 4 Tim Swinson, 3 Euan Murray, 2 Scott Lawson, 1 Alasdair Dickinson.
Replacements: 16 Stevie Lawrie, 17 Jon Welsh, 18 Moray Low, 19 Alastair Kellock, 20 David Denton, 21 Henry Pyrgos, 22 Peter Horne, 23 Duncan Taylor.
Date: Saturday, June 15
Venue: Mbombela Stadium, Nelspruit
Kick-off: 17.15 (15.15 GMT; 16.15 UK time)
Referee: Romain Poite (France)
Assistant referees: Pascal Gauzère (France), Nigel Hennessy (Wales)
TMO: Gerrie Coetzee (South Africa)