It’s a great challenge and one we are all looking forward to
London Irish wing Marland Yarde will win his first England cap when they take on Argentina in Buenos Aires on Saturday.
Bath Rugby’s Kyle Eastmond, who made his Test debut in last Saturday’s 32-3 win in Salta, will start for the first time in the No.12 jersey vacated by Lions-bound centre Billy Twelvetrees.
And flyhalf Stephen Myler will win a first cap if he comes off the replacements’ bench.
England are bidding to secure a first series win in Argentina since 1981, when Bill Beaumont’s tourists drew the first and won the second of their two Tests.
Head Coach Stuart Lancaster said: "It is great to reward young players who have pushed through this season. They have worked hard to earn their opportunities on this tour.
"This is a young England side which made a very positive start to the series in Salta. But we expect Argentina to come back very strongly in front of a big home crowd.
"It’s a great challenge and one we are all looking forward to," Lancaster added.
England: 15 Mike Brown, 14 Christian Wade, 13 Jonathan Joseph, 12 Kyle Eastmond, 11 Marland Yarde, 10 Freddie Burns, 9 Lee Dickson, 8 Ben Morgan, 7 Matt Kvesic, 6 Tom Wood (captain), 5 Dave Attwood, 4 Joe Launchbury, 3 David Wilson, 2 Rob Webber, 1 Joe Marler.
Replacements: 16 David Paice, 17 Paul Doran Jones, 18 Henry Thomas, 19 Courtney Lawes, 20 Billy Vunipola, 21 Richard Wigglesworth, 22 Stephen Myler, 23 Ben Foden.
Date: Saturday, 15 June
Venue: Velez Sarsfield Stadium, Buenos Aires
Kick-off: 16.10 (19.10 GMT)
Referee: Nigel Owens (Wales)
Assistant referees: Marius Jonker (South Africa), Christie du Preez (South Africa)
TMO: Shaun Veldsman (South Africa)