The Ireland coaching team has made just one change to the starting XV that narrowly lost to England, for the Six Nations clash against Italy in Dublin on Saturday.
Iain Henderson lines out at blindside flank in place of the sidelined Peter O'Mahony and will form a back row partnership with Ulster colleague Chris Henry and Ireland vice-captain Jamie Heaslip.
Paul O'Connell leads the side and packs down in an unchanged front five alongside Devin Toner, Cian Healy, Rory Best and Mike Ross.
Johnny Sexton has recovered from a thumb injury to take his place in the backline that started against England and Wales.
There are a couple of changes on the bench - with Rhys Ruddock replacing Henderson who starts and Eoin Reddan coming in for Isaac Boss who is rested this week.
Brian O'Driscoll becomes the most capped Test player in history, claiming his 140th international appearance (132 Ireland and eight for the B&I Lions).
Ireland: 15 Rob Kearney, 14 Andrew Trimble, 13 Brian O'Driscoll, 12 Gordon D'Arcy, 11 Dave Kearney, 10 Jonathan Sexton, 9 Conor Murray, 8 Jamie Heaslip, 7 Chris Henry, 6 Iain Henderson, 5 Paul O'Connell (captain), 4 Devin Toner, 3 Mike Ross, 2 Rory Best, 1 Cian Healy.
Replacements: 16 Sean Cronin, 17 Jack McGrath, 18 Martin Moore, 19 Rhys Ruddock, 20 Jordi Murphy, 21 Eoin Reddan, 22 Paddy Jackson, 23 Fergus McFadden.
Date: Saturday, March 8
Venue: Aviva Stadium, Dublin
Kick-off: 14.30 (14.30 GMT)
Referee: Romain Poite (France)
Assistant referees: Steve Walsh (Australia), Lourens van der Merwe (South Africa)
TMO: Simon McDowell (Ireland)