Will be without Sean O'Brien, Cian Healy, Gordon D'Arcy and Tommy Bowe
The South African-born Ulster duo of Robbie Diack and Rob Herring have both been named in Ireland's 30-man squad to tour Argentina next month.
Ireland coach Joe Schmidt has rested four of his most experienced players and included an uncapped quartet, with prop James Cronin and scrumhalf Kieran Marmion included along with loose forward Diack and hooker Herring.
In what will be Ireland's first Test series since the retirement of centre great Brian O'Driscoll, the 2014 Six Nations champions will be without Sean O'Brien, Cian Healy, Gordon D'Arcy and Tommy Bowe, who've all been given a break by Schmidt.
Meanwhile promising Leinster flyhalf Ian Madigan will travel to Romania with the Emerging Ireland team.
A squad captained by veteran lock Paul O'Connell is due to leave for Buenos Aires on June 1, the day after the Pro12 final between Leinster and Glasgow.
Ireland squad: Darren Cave, Keith Earls, Robbie Henshaw, Paddy Jackson, Felix Jones, Rob Kearney, Kieran Marmion, Luke Marshall, Fergus McFadden, Conor Murray, Eoin Reddan, Jonathan Sexton, Andrew Trimble, Simon Zebo, Rory Best, James Cronin, Robbie Diack, Iain Henderson, Chris Henry, Jamie Heaslip, Rob Herring, Dave Kilcoyne, Jack McGrath, Marty Moore, Jordi Murphy, Paul O'Connell (captain), Mike Ross, Rhys Ruddock, Devin Toner, Damian Varley.
June 7: Argentina v Ireland, Resistencia
June 14: Argentina v Ireland, Tucuman