Ireland coach Joe Schmidt made seven changes and a positional switch to his side ahead of the second and final Test against Argentina.
The Pumas host the men from the Emerald Isle in Tucuman on Saturday, after they lost 17-29 to the Irish in Resistencia last Saturday.
Leinster's Rhys Ruddock will make his first start for Ireland, winning his third cap in a back row that contains Chris Henry and Jamie Heaslip who returns at No.8.
Devin Toner also comes back into the starting line-up, rejoining captain Paul O'Connell in the second row.
O'Connell's Munster colleague Dave Kilcoyne is set for his second start in 10 Tests in the front row.
Rob Kearney replaces Felix Jones at fullback with both wings, Andrew Trimble and Simon Zebo, retained from the opening Test win last weekend.
Fergus McFadden is promoted from the bench to wear the No.13 jersey, with Darren Cave switching to inside centre.
It will be McFadden's first start at outside centre since the 2012 Six Nations game against Wales.
Eoin Reddan comes in at scrumhalf some seven years on from his first start in green during the 2007 mid-year tour to Argentina.
There are three uncapped players on the replacements bench - Ulster hooker Rob Herring, Munster prop James Cronin and Leinster's Noel Reid.
Ireland: 15 Rob Kearney, 14 Andrew Trimble, 13 Fergus McFadden, 12 Darren Cave, 11 Simon Zebo, 10 Jonathan Sexton, 9 Eoin Reddan, 8 Jamie Heaslip, 7 Chris Henry, 6 Rhys Ruddock, 5 Paul O'Connell (captain), 4 Devin Toner, 3 Mike Ross, 2 Rory Best. 1 Dave Kilcoyne.
Replacements: 16 Rob Herring, 17 James Cronin, 18 Jack McGrath, 19 Iain Henderson, 20 Jordi Murphy, 21 Conor Murray, 22 Ian Madigan, 23 Noel Reid.
Date: Saturday, June 14
Venue: Estadio José Fierro, Tucumán
Kick-off: 15.40 (18.40 GMT, 19.40 BST)
Referee: Pascal Gauzère (France)
Assistant referees: Glen Jackson (New Zealand), John Lacey (Ireland)
TMO: Shaun Veldsman (South Africa)