Lyon's South African prop Wian Du Preez and French flank Pierrick Gunther were both due to undergo operations on Monday.
England flyhalf Toby Flood made a memorable Top 14 debut for Toulouse, scoring all their points in a 20-19 victory over Oyonnax.
Defending champions Toulon began life after Jonny Wilkinson with a battling 29-15 victory at Bayonne on the opening day of the new Top 14 season.
Toulon hooker Guilhem Guirado has been drafted into the France elite squad of 30 for the upcoming season, in preparation for the 2015 World Cup.
The French Top 14 competition gets underway this coming weekend and, as usual, there has been plenty of player movement in the off-season.
All Black Sitiveni Sivivatu is to miss three-and-a-half-months of the forthcoming season after undergoing a shoulder operation.
Toulon open the defence of their Top 14 crown against Bayonne, with a sprinkling of foreign talent making up for the absence of Jonny Wilkinson and Joe van Niekerk.
The French Rugby Federation (FFR) said it will toughen its stance with Top 14 clubs over their assessing of whether players are concussed during a match.
Former Springbok prop CJ van der Linde has not been signed by Toulon where he has been on trial as a potential replacement for Martin Castrogiovanni.
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