Wales captain Sam Warburton is set to miss the rest of the European season and the tour of South Africa, after suffering a suspected dislocated shoulder.
Scotland's Stuart Hogg made a public apology after being sent off during his side's record Six Nations defeat by Wales in Cardiff at the weekend.
Warren Gatland accepts he will have to change his tactics if Wales are to return to the summit of European rugby.
Wales finished their Six Nations campaign on a victorious note, beating Scotland 51-3 in a seven-try rout in Cardiff on Saturday.
Wales fullback Leigh Halfpenny will be out for up to four months after dislocating his right shoulder against England.
Although their hopes of a third consecutive Six Nations title are gone, Wales will be looking to end their campaign on a high against Scotland on Saturday.
Dougie Fife, the 23-year-old Edinburgh wing, becomes the second new cap of Scotland's 2014 Six Nations Championship campaign.
Wales coach Warren Gatland made six changes to his side to play Scotland, as they look to finish the Six Nations with a flourish.
Scotland head coach Scott Johnson has named a 13-man squad of backs from which he will finalise selection for after Thursday's training.
Back row forward Johnnie Beattie and wing Sean Lamont will both miss Scotland's final match in the Six Nations due to injury.
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