Wallabies to unleash Koroibete against Los Pumas
Simmons will line-up in Canberra for his 75th Test cap alongside Adam Coleman with Rory Arnold left out of the matchday squad.
Queensland Reds lock Izack Rodda will get the chance to claim his second Test cap if called upon from the bench for Saturday's international.
Former National Rugby League wing Koroibete was also named among the replacements and is set to become the 10th Wallabies debutant this year.
Koroibete, who played for the Melbourne Storm in the NRL before switching to the Melbourne Rebels, displaces Curtis Rona among the reserves.
Rebels teammate Jordan Uelese holds on to his spot on the bench ahead of former skipper Stephen Moore.
Moore returned to the Wallabies camp this week after missing last week's 23-23 draw with the Springboks in Perth due to the birth of his third child.
But coach Michael Cheika preferred youngster Uelese, who made an assured debut last weekend and will have the back-up role to starting hooker Tatafu Polota-Nau.
Australia are currently third on the Rugby Championship standings following a draw and two defeats while Argentina are yet to register a point after two defeats to South Africa and another loss to New Zealand.
The Wallabies have won their last four games against the Pumas while Argentina have won only once in Australia with an 18-3 victory in Brisbane in 1983.
Australia: 15 Israel Folau, 14 Henry Speight, 13 Tevita Kuridrani, 12 Kurtley Beale, 11 Reece Hodge, 10 Bernard Foley, 9 Will Genia, 8 Sean McMahon, 7 Michael Hooper (captain), 6 Ned Hanigan, 5 Adam Coleman, 4 Rob Simmons, 3 Sekope Kepu, 2 Tatafu Polota-Nau, 1 Scott Sio.
Replacements: 16 Jordan Uelese, 17 Tom Robertson, 18 Allan Alaalatoa, 19 Izack Rodda, 20 Jack Dempsey, 21 Nick Phipps, 22 Samu Kerevi, 23 Marika Koroibete.
Date: Saturday, September 14
Venue: GIO Stadium, Canberra
Kick-off: 20.00 (07.00 Argentina Time; 10.00 GMT)
Referee: John Lacey (Ireland)
Assistant referees: Glen Jackson (New Zealand), Paul Williams (New Zealand)
TMO: Ben Skeen (New Zealand)
Agence France-Presse
