Jones gives Farrell the inside line
It will be Eddie Jones' first game as head coach.
Jones has chosen Owen Farrell at inside centre, while Danny Care starts at scrumhalf.
Joe Marler is named at loosehead prop with George Kruis partnering Joe Launchbury in the second row.
Courtney Lawes is fit enough to be named among the replacements which include three debutants – Jack Clifford, Paul Hill and Ollie Devoto.
Harlequins' Chris Robshaw starts at blind-side flanker, James Haskell is installed at openside with Billy Vunipola at No.8.
Vunipola is one of three vice-captains along with Farrell and fullback Mike Brown.
Between them Jones' side have 512 international caps as they aim to retain the Calcutta Cup, a trophy they have held since 2008.
"There were some tight calls on selection, but we have picked a match-day squad with a blend of experience and youth," said Jones.
"The boys have worked hard since coming into camp to understand how I want the team to play going forward.
"We have prepared well and I am pleased with the progress the group has made in the short time we've had together."
Jones also thanked previous Head Coach Stuart Lancaster, adding he was positive England can seal victory in Scotland,
"We are indebted to the work Stuart Lancaster has done over the last four years," he said.
"I have inherited a talented and highly motivated group of players.
"We are confident we can go to Edinburgh and win, but we're in no doubt it will be a huge challenge. Playing at Murrayfield in front of a passionate Scottish crowd will be a real test for this team but one I know we can rise to."
Date: Saturday, February 6
Venue: Murrayfield, Edinburgh
Kick-off: 16.50 (16.50 GMT)
Referee: John Lacey (Ireland)
Assistant referees: Romain Poite (France), Stuart Berry (South Africa)
TMO: George Ayoub (Australia)
