Los Pumas backs favoured front row
Coach Daniel Hourcade has made seven changes to the team that beat Georgia – bringing back Guido Petti, Tomas Lavanini, Pablo Matera and Leonardo Senatore.
Jerónimo De la Fuente and Matias Moroni replace Juan Martin Hernandez and Marcelo Bosch, who started both of Argentina's previous matches The two young centres have never started a Test together.
Tighthead prop Nahuel Tetaz Chaparro, who also started Argentina's first two matches, is replaced by Ramiro Herrera.
The front row trio of Marcos Ayerza, Agustin Creevy and Herrera is coach Hourcade's favourite combination as they have started eight of Argentina's matches, the last of which was the 9-34 defeat by Australia in this year's Rugby Championship.
Argentina have lost all eight matches in which that trio has started together in the front row, although all eight were against Australia, New Zealand or South Africa.
On the wing, Juan Imhoff needs one try to break the Argentina World Cup record of four – which he currently shares with four other players.
Having overtaken his brother Ignacio's number of caps in the last match, Juan Martin Fernandez Lobbe now equals Ignacio in terms of World Cup matches (13) Mario Ledesma leads that list with 18 World Cup matches for the Pumas.
With an average age of 26 years and 236 days, Argentina are fielding their youngest team since their quarterfinal defeat by France at the 1999 edition of the tournament and a team that is around a year per man younger than the one which that against Georgia.
Argentina: 15 Joaquin Tuculet, 14 Santiago Cordero, 13 Matias Moroni, 12 Jerónimo De La Fuente, 11 Juan Imhoff, 10 Nicolas Sanchez, 9 Martin Landajo, 8 Leonardo Senatore, 7 Juan Martin Fernandez Lobbe, 6 Pablo Matera, 5 Tomas Lavanini, 4 Guido Petti, 3 Ramiro Herrera, 2 Agustin Creevy (captain), 1 Marcos Ayerza.
Replacements: 16 Julian Montoya, 17 Lucas Noguera, 18 Juan Pablo Orlandi, 19 Matias Alemanno, 20 Juan Manuel Leguizamon, 21 Tomas Cubelli, 22 Santiago Gonzalez Iglesias, 23 Horacio Agulla.
Date: Sunday, October 4
Venue: Leicester City Stadium, Leicester
Kick-off: 14.30 (13.30 GMT; 10.30 ART; Monday, October 5, 02.30 Tonga Time)
Referee: Jaco Peyper (South Africa)
Assistant referees: Glen Jackson (New Zealand), Mike Fraser (New Zealand)
TMO: Ben Skeen (New Zealand)
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