Cubelli at scrumhalf for Pumas
Following last week's 19-16 defeat to Scotland the three changes see scrumhalf Tomás Cubelli replacing Martín Landajo.
While the inclusion of Santiago Gonzalez Iglesias at inside centre will ensure Juan Martín Hernández moving into the flyhalf positon ahead of Nicolás Sánchez, who has been dropped.
In the back row No.8 Leonardo Senatore has replaced Facundo Isa.
This will be the twenty-first time that these teams meet with a record 14 wins England, four for Argentina and two draws.
The last time the Pumas won at Twickenham was in 2006, with Juan Martin Hernandez being part of the 25-18 victory.
Hourcade said his team would have to be at their best against an England side on a 12-game winning streak, the last 11 all under Australian coach Eddie Jones.
"Even though the perfect match doesn't exist, we have to play the best game possible, because England are in a great place and they're a very good team," said Hourcade.
"It's a very tough challenge, and we'll have to be up to the task," he added.
Argentina: 15 Joaquín Tuculet, 14 Matías Orlando, 13 Matías Moroni, 12 Santiago González Iglesias, 11 Santiago Cordero, 10 Juan Martín Hernández, 9 Tomás Cubelli, 8 Leonardo Senatore, 7 Javier Ortega Desio, 6 Pablo Matera, 5 Matías Alemanno, 4 Guido Petti, 3 Ramiro Herrera, 2 Agustín Creevy (captain), 1 Lucas Noguera.
Replacement: 16 Julián Montoya, 17 Santiago García Botta, 18 Enrique Pieretto, 19 Facundo Isa, 20 Tomas Lezana, 21 Tomás Cubelli,22 Jerónimo De la Fuente, 23 Juan Pablo Estelles.
Date: Saturday, November 26
Venue: Twickenham Stadium, London
Kick-off: 14.30 (14.30 GMT; 11.30 ART)
Referee: Pascal Gauzère (France)
Assistant referees: Marius Mitrea (Italy), Ian Davies (Wales)
TMO: Gareth Simmonds (Wales)
