More injury woes for France
More injury woes for FranceSHARE
The squad have already lost Clermont centre Wesley Fofana, who ruptured an Achilto fixles tendon in the side's European Champions Cup win over Exeter on Saturday.
Then the man named to replace him, Racing 92's Henry Chavancy, pulled out with a damaged collar bone after Sunday's defeat to Munster.
Racing prop Eddy Ben Arous was also ruled out through injury.
Lakafia, who picked up a knee injury playing in Stade Français's European Challenge Cup win against Harlequins on Saturday, has not been replaced in the squad, but Christopher Tolofua comes in for Chat.