Henderson returns for Ireland
Henderson returns for IrelandSHARE
The change comes at second row, where Iain Henderson is preferred to Devin Toner, who drops to the bench.
Last week's man of the match Rob Kearney retains his place in the starting XV, with Leinster prospect Jordan Larmour on the bench.
Ireland sewed up the Six nations title last weekend, but could win a third ever Grand Slam with a win over England on St Patrick's Day.
"There's a sense of anticipation, there's a sense of nervousness," said Schmidt.
"The magnitude of what it's going to take to get us over the line is very much uppermost in the thinking.
"It was a bit of a plan over last few days to mix things up in the second row.
"Iain has got a little bit of time under his belt after having a couple of weeks off, so we think he has progressed a little bit further and is more ready to go."
Ireland: 15 Rob Kearney, 14 Keith Earls, 13 Garry Ringrose, 12 Bundee Aki, 11 Jacob Stockdale, 10 Johnny Sexton, 9 Conor Murray, 8 Christiaan Stander, 7 Dan Leavy, 6 Peter O’Mahony, 5 Iain Henderson, 4 James Ryan, 3 Tadhg Furlong, 2 Rory Best (captain), 1 Cian Healy.
Replacements: 16 Sean Cronin, 17 Jack McGrath, 18 Andrew Porter, 19 Devin Toner, 20 Jordi Murphy, 21 Kieran Marmion, 22 Joey Carbery, 23 Jordan Larmour.
Date: Saturday, March 17
Venue: Twickenham, London
Kick-off: 14.45 (14.45 GMT)
Referee: Angus Gardner (Australia)
Assistant Referees: Jaco Peyper (South Africa), Nigel Owens (Wales)
TMO: Ben Skeen (New Zealand)