Bonilla on Jaguares debut against Kings
Joaquín Díaz Bonilla, who will start at flyhalf in Port Elizabeth on Saturday, is the only uncapped player in the run-on team.
Prop Cristian Bartoloni could also make his Super Rugby debut if he comes off the bench.
Most of the changes to the team are injury enforced.
Bonilla is in the No.10 jersey in the place of the injured Nicolas Sánchez.
Gonzalo Bertranou will start at No.9 in the absence of regular scrumhalf Martín Landajo – who is also sidelined with an injury for the first few rounds of the competition.
Argentina stalwart Juan Martín Hernández is injured, meaning Jerónimo de la Fuente will start at inside centre for the Jaguares and he will be partnered by Matías Moroni at outside centre.
In the forward pack Facundo Isa, who is on his way to France, is replaced by Leonardo Senatore at No.8. Pablo Matera and Tomás Lezana are the flanks.
Pérez named a strong tight five – with Matías Alemanno and Guido Petti in the second row, while Felipe Arregui, Agustín Creevy and Lucas Noguera Paz make up the front row.
"We think that these 23 players are the most suitable for the rival that we are going to have on Saturday," Perez said.
Jaguares: 15 Joaquín Tuculet, 14 Matías Orlando, 13 Matías Moroni, 12 Jerónimo de la Fuente, 11 Santiago Cordero, 10 Joaquín Díaz Bonilla, 9 Gonzalo Bertranou, 8 Leonardo Senatore, 7 Pablo Matera, 6 Tomás Lezana, 5 Matías Alemanno, 4 Guido Petti, 3 Felipe Arregui, 2 Agustín Creevy (captain), 1 Lucas Noguera Paz.
Replacements: 16 Julián Montoya, 17 Santiago García Botta, 18 Cristian Bartoloni, 19 Marcos Kremer, 20 Rodrigo Báez, 21 Felipe Ezcurra, 22 Santiago González Iglesias, 23 Ramiro Moyano.
Date: Saturday, February 25
Venue: Nelson Mandela Bay Stadium, Port Elizabeth
Kick-off: 17.15 (12.15 Argentina time; 15.15 GMT)
Referee: Jaco Peyper (South Africa)
Assistant referees: AJ Jacobs (South Africa), Archie Sehlako (South Africa)
TMO: Johan Greeff (South Africa)
